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PDBsum entry 7qkd
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PDB id:
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Hydrolase
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Title:
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Crystal structure of human cathepsin l in complex with covalently bound mg132
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Structure:
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Cathepsin l. Chain: a, b, c, d. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223
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Resolution:
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1.50Å
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R-factor:
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0.180
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R-free:
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0.198
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Authors:
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P.Y.A.Reinke,S.Falke,J.Lieske,W.Ewert,J.Loboda,A.Rahmani Mashhour, M.Hauser,K.Karnicar,A.Usenik,N.Lindic,M.Lach,H.Boehler,T.Beck,R.Cox, H.N.Chapman,W.Hinrichs,D.Turk,S.Guenther,A.Meents
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Key ref:
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P.Y.A.Reinke
et al.
Sulfonated calpeptin is a promising drug candidate ag sars-Cov-2 infections.
To be published,
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PubMed id:
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Date:
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17-Dec-21
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Release date:
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28-Dec-22
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PROCHECK
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Headers
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References
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P07711
(CATL1_HUMAN) -
Procathepsin L from Homo sapiens
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Seq:
Struc:
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333 a.a.
220 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.4.22.15
- cathepsin L.
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Reaction:
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Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
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Links
