PDBsum entry 7q1c

Hydrolase

PDB id: 7q1c

Contents

Protein chains

427 a.a.

Ligands

T56 ×2

Metals

_ZN ×2

__K ×4

Waters ×230

PDB id:

7q1c

Name:

Hydrolase

Title:

Crystal structure of trypanosoma cruzi histone deacetylase dac2 complexed with a hydroxamate inhibitor

Structure:

Histone deacetylase dac2. Chain: a, b. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.30Å R-factor: 0.198 R-free: 0.224

Authors:

E.Ramos-Morales,M.Marek,C.Romier

Key ref:

M.Marek et al. Species-Selective targeting of pathogens revealed by atypical structure and active site of trypanosoma cru histone deacetylase dac2. To be published, . PubMed id: 34936867

Date:

18-Oct-21 Release date: 15-Dec-21

Protein chains

A0A1B1JH81  (A0A1B1JH81_TRYCR) -  histone deacetylase from Trypanosoma cruzi

Seq: 516 a.a.

Struc: 427 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?