PDBsum entry 7pvs

Protein binding

PDB id: 7pvs

Contents

Protein chains

58 a.a.

59 a.a.

Ligands

PGE

SO4 ×3

PEG

P6G

Metals

_NA

Waters ×141

PDB id:

7pvs

Name:

Protein binding

Title:

Crystal structure of the abl sh3 domain v73e-a74s-s75r-g76t-d77e-g92n- y93n-n94t-h95e mutant in presence of peg 200

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Synonym: abelson murine leukemia viral oncogene homolog 1,abelson tyrosine-protein kinase 1,proto-oncogenE C-abl,p150. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.05Å R-factor: 0.170 R-free: 0.184

Authors:

A.Camara-Artigas,M.C.Salinas Garcia

Key ref:

A.Camara-Artigas and m.c.salinas garcia The effect of the hinge loops composition in the doma swapping of the sh3 domain. To be published, . PubMed id: 40862305

Date:

05-Oct-21 Release date: 14-Sep-22

Protein chain

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 58 a.a.*

Protein chain

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 59 a.a.*

* PDB and UniProt seqs differ at 19 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site