PDBsum entry 7pim

Oxidoreductase

PDB id: 7pim

Contents

Protein chains

335 a.a.

18 a.a.

Ligands

LDP ×4

Metals

_FE ×4

PDB id:

7pim

Name:

Oxidoreductase

Title:

Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine.

Structure:

Tyrosine 3-monooxygenase. Chain: b, a, d, f. Synonym: tyrosine 3-hydroxylase,th. Engineered: yes. Regulatory domain alpha-helix. Chain: g, c, e, h. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: th, tyh. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Authors:

M.T.Bueno-Carrasco,J.Cuellar,C.Santiago,J.M.Valpuesta,A.Martinez, M.I.Flydal

Key ref:

M.T.Bueno-Carrasco et al. (2022). Structural mechanism for tyrosine hydroxylase inhibit dopamine and reactivation by ser40 phosphorylation.. Nat commun, 13, 74. PubMed id: 35013193

Date:

20-Aug-21 Release date: 22-Dec-21

Protein chains

P07101  (TY3H_HUMAN) -  Tyrosine 3-monooxygenase from Homo sapiens

Seq: 528 a.a.

Struc: 335 a.a.

Protein chains

P07101  (TY3H_HUMAN) -  Tyrosine 3-monooxygenase from Homo sapiens

Seq: 528 a.a.

Struc: 18 a.a.

Enzyme reactions

• Enzyme class: Chains B, G, A, C, D, E, F, H: E.C.1.14.16.2 - tyrosine 3-monooxygenase.
• Pathway: Dopa Biosynthesis
• Reaction: (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)- 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)- 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa (Bound ligand (Het Group name = LDP) matches with 78.57% similarity)

• Cofactor: Fe cation

Molecule diagrams generated from .mol files obtained from the KEGG ftp site