PDBsum entry 7ovh

Hydrolase

PDB id: 7ovh

Contents

Protein chain

232 a.a.

Ligands

ACT ×2

UNL

Metals

_ZN ×3

Waters ×116

PDB id:

7ovh

Name:

Hydrolase

Title:

Crystal structure of the vim-2 acquired metallo-beta-lactamase in complex with compound 14 (jmv-6931)

Structure:

Metallo-beta-lactamase vim-2-like protein. Chain: a. Engineered: yes

Source:

Pseudomonas aeruginosa. Organism_taxid: 287. Gene: blavim. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.80Å R-factor: 0.185 R-free: 0.236

Authors:

G.Tassone,M.Benvenuti,F.Verdirosa,F.Sannio,F.Marcoccia,J.D.Docquier, C.Pozzi,S.Mangani

Key ref:

A.Legru et al. (2021). 1,2,4-Triazole-3-Thione compounds with a 4-Ethyl alky sulfide substituent are broad-Spectrum metallo-Beta-Lactamase inhibitors with re-Sensitizati activity.. Eur j med chem, 226, 13873. PubMed id: 34626878

Date:

14-Jun-21 Release date: 20-Oct-21

Protein chain

Q9K2N0  (Q9K2N0_PSEAI) -  Beta-lactamase from Pseudomonas aeruginosa

Seq: 266 a.a.

Struc: 232 a.a.

Enzyme reactions

• Enzyme class: E.C.?