PDBsum entry 7org

Signaling protein

PDB id: 7org

Contents

Protein chain

231 a.a.

Ligands

ARG-ARG-ARG-GLN-TPO

09W ×2

Metals

_MG ×2

_CL

Waters ×314

PDB id:

7org

Name:

Signaling protein

Title:

Ternary complex of 14-3-3 sigma, p27pt198 phosphopeptide, and wq162

Structure:

14-3-3 protein sigma. Chain: a. Synonym: epithelial cell marker protein 1,stratifin. Engineered: yes. Cyclin-dependent kinase inhibitor 1b. Chain: p. Synonym: cyclin-dependent kinase inhibitor p27,p27kip1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sfn, hme1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.80Å R-factor: 0.162 R-free: 0.202

Authors:

F.Centorrino,Q.Wu,C.Ottmann

Key ref:

F.Centorrino et al. A crystallography-Based study of fragment extensions the 14-3-3 binding groove. To be published, .

Date:

05-Jun-21 Release date: 22-Jun-22

Protein chain

P31947  (1433S_HUMAN) -  14-3-3 protein sigma from Homo sapiens

Seq: 248 a.a.

Struc: 231 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)