PDBsum entry 7ops

Transferase

PDB id: 7ops

Contents

Protein chain

328 a.a.

Ligands

07C

GOL

Waters ×155

PDB id:

7ops

Name:

Transferase

Title:

Crystal structure of haspin in complex with zw282 (compound 2a)

Structure:

Serine/threonine-protein kinase haspin. Chain: a. Synonym: germ cell-specific gene 2 protein,h-haspin,haploid germ cell-specific nuclear protein kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: haspin, gsg2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: -r3-prare2.

Resolution:

2.38Å R-factor: 0.179 R-free: 0.229

Authors:

A.Chaikuad,F.Anizon,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

W.Zeinyeh et al. (2022). Synthesis and biological evaluation of haspin inhibit kinase inhibitory potency and cellular activity.. Eur j med chem, 236, 14369. PubMed id: 35447555

Date:

01-Jun-21 Release date: 21-Jul-21

Protein chain

Q8TF76  (HASP_HUMAN) -  Serine/threonine-protein kinase haspin from Homo sapiens

Seq: 798 a.a.

Struc: 328 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site