PDBsum entry 7okc

Transferase

PDB id: 7okc

Contents

Protein chain

264 a.a.

Ligands

VFE

Metals

_NA

Waters ×186

PDB id:

7okc

Name:

Transferase

Title:

Crystal structure of escherichia coli lpxa in complex with compound 1

Structure:

Acyl-[acyl-carrier-protein]--udp-n-acetylglucosamine o- acyltransferase. Chain: a. Fragment: full-length protein. Synonym: udp-n-acetylglucosamine acyltransferase. Engineered: yes

Source:

Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss.

Resolution:

1.84Å R-factor: 0.176 R-free: 0.218

Authors:

M.D.Ryan,A.L.Parkes,M.Southey,O.A.Andersen,M.Zahn,J.Barker, B.L.M.Dejonge

Key ref:

M.D.Ryan et al. Discovery of novel udp- N -Acetylglucosamine acyltran (lpxa) inhibitors with activity against pseudomonas aeruginosa .. J med chem, . PubMed id: 34569791

Date:

17-May-21 Release date: 06-Oct-21

Protein chain

C3TPH2  (C3TPH2_ECOLX) -  Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase from Escherichia coli

Seq: 262 a.a.

Struc: 264 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.1.129 - acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.
• Reaction: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3- O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]

Molecule diagrams generated from .mol files obtained from the KEGG ftp site