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PDBsum entry 7oft
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PDB id:
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Hydrolase
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Title:
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Structure of sars-cov-2 papain-like protease plpro in complex with p- hydroxybenzaldehyde
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Structure:
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Papain-like protease nsp3. Chain: a. Synonym: non-structural protein 3,nsp3,pl2-pro,papain-like proteinase,pl-pro. Engineered: yes
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Source:
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Severe acute respiratory syndrome coronavirus 2. 2019-ncov, sars-cov-2. Organism_taxid: 2697049. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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1.95Å
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R-factor:
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0.182
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R-free:
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0.212
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Authors:
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V.Srinivasan,N.Werner,S.Falke,S.Guenther,P.Reinke,H.Brognaro,N.Ullah, H.Andaleeb,M.Perbandt,B.Alves Franca,M.Schwinzer,M.Wang,W.Ewert, J.Sprenger,J.Lieske,F.Koua,H.Ginn,T.J.Lane,M.Wolf,O.Yefanov, L.Gelisio,S.Saouane,A.Tolstikova,M.Groessler,H.Fleckenstein,F.Trost, K.Lorenzen,R.Schubert,H.Han,C.Schmidt,L.Brings,M.Galchenkova, Y.Gevorkov,C.Li,A.Perk,S.Awel,A.Wahab,I.Choudary,D.Turk,W.Hinrichs, H.N.Chapman,A.Meents,C.Betzel
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Key ref:
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v.srinivasan
et al.
(2022).
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol,
5,
805-805.
PubMed id:
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Date:
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05-May-21
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Release date:
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12-May-21
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PROCHECK
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Headers
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References
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Enzyme class:
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E.C.3.4.19.12,3.4.22.-
- ubiquitinyl hydrolase 1.
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Reaction:
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Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
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Commun Biol
5:805-805
(2022)
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PubMed id:
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Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
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v.srinivasan,
n.werner,
s.falke,
s.guenther,
p.reinke,
w.ej.sprenger,
f.koua,
h.brognaro,
n.ullah,
h.andaleeb,
m.perb.alves franca,
m.schwinzer,
m.wang,
j.lieske,
h.ginn,
t.jo.yefanov,
l.gelisio,
j.hakanpaeae,
s.saouane,
a.tolstikom.groessler,
h.fleckenstein,
f.trost,
m.wolf,
k.lorenzen,
r.schubert,
h.han,
c.schmidt,
l.brings,
m.galchenkova,
y.gevorkov,
c.li,
a.perk,
s.awel,
a.wahab,
i.choudary,
d.tuw.hinrichs,
h.n.chapman,
a.meents,
c.betzel.
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ABSTRACT
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