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PDBsum entry 7oeh
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protein ligands Protein-protein interface(s) links
Transferase PDB id
7oeh

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
201 a.a.
239 a.a.
Ligands
6IK
ACT
Waters ×207
PDB id:
7oeh
Name: Transferase
Title: Crystal structure of the human mettl3-mettl14 complex with compound uoz059b
Structure: N6-adenosine-methyltransferase catalytic subunit. Chain: a. Synonym: methyltransferase-like protein 3,hmettl3,n6-adenosine- methyltransferase 70 kda subunit,mt-a70. Engineered: yes. N6-adenosine-methyltransferase non-catalytic subunit. Chain: b. Synonym: methyltransferase-like protein 14,hmettl14. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mettl3, mta70. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mettl14, kiaa1627. Expression_system_taxid: 7108
Resolution:
2.01Å     R-factor:   0.204     R-free:   0.229
Authors: R.K.Bedi,D.Huang,A.Caflisch
Key ref: R.K.Bedi et al. Crystal structure of the human mettl3-Mettl14 complex compound uoz059b. To be published, .
Date:
03-May-21     Release date:   20-Oct-21    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q86U44  (MTA70_HUMAN) -  N6-adenosine-methyltransferase catalytic subunit from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		580 a.a.
201 a.a.
Protein chain
Pfam   ArchSchema ?
Q9HCE5  (MET14_HUMAN) -  N6-adenosine-methyltransferase non-catalytic subunit from Homo sapiens
Seq:
Struc: 		456 a.a.
239 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: Chain A: E.C.2.1.1.348  - mRNA m(6)A methyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N6-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H+
adenosine in mRNA
 + S-adenosyl-L-methionine
 = N(6)-methyladenosine in mRNA
 + S-adenosyl-L-homocysteine
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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