PDBsum entry 7o5c

Peptide binding protein

PDB id: 7o5c

Contents

Protein chain

227 a.a.

Ligands

ALA-GLY-SEP-ILE-PRO-GLY-ARG-ARG-SER

V2T

GOL

Metals

_CL

Waters ×302

PDB id:

7o5c

Name:

Peptide binding protein

Title:

14-3-3 sigma with rela/p65 binding site ps45 and covalently bound tcf521-159

Structure:

14-3-3 protein sigma. Chain: a. Synonym: epithelial cell marker protein 1,stratifin. Engineered: yes. Transcription factor p65. Chain: p. Synonym: nuclear factor nf-kappa-b p65 subunit,nuclear factor of kappa light polypeptide gene enhancer in b-cells 3. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sfn, hme1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.80Å R-factor: 0.193 R-free: 0.227

Authors:

M.Wolter,C.Ottmann

Key ref:

M.Wolter et al. An exploration of chemical properties required for cooperative stabilization of the 14-3-3 interaction w nf-Kappa b-Utilizing a reversible covalent tethering approach.. J med chem, . PubMed id: 34076416

Date:

08-Apr-21 Release date: 09-Jun-21

Protein chain

P31947  (1433S_HUMAN) -  14-3-3 protein sigma from Homo sapiens

Seq: 248 a.a.

Struc: 227 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)