PDBsum entry 7o3c

Membrane protein

PDB id: 7o3c

Contents

Protein chains

446 a.a.

420 a.a.

379 a.a.

241 a.a.

196 a.a.

102 a.a.

74 a.a.

68 a.a.

58 a.a.

52 a.a.

60 a.a.

78 a.a.

111 a.a.

514 a.a.

227 a.a.

259 a.a.

144 a.a.

104 a.a.

95 a.a.

75 a.a.

79 a.a.

72 a.a.

49 a.a.

46 a.a.

43 a.a.

Ligands

3PE ×15

CDL ×7

HEM ×4

HEC ×2

FES ×2

PC1 ×3

HEA ×2

CUA

TGL

Metals

_ZN

_CU

_NA

_MG

PDB id:

7o3c

Name:

Membrane protein

Title:

Murine supercomplex ciii2civ in the mature unlocked conformation

Structure:

Cytochrome b-c1 complex subunit 1, mitochondrial. Chain: a, l. Synonym: complex iii subunit 1,core protein i,ubiquinol-cytochromE-C reductase complex core protein 1. Cytochrome b-c1 complex subunit 2, mitochondrial. Chain: b, m. Synonym: complex iii subunit 2,core protein ii,ubiquinol-cytochromE-C reductase complex core protein 2. Cytochrome b.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Organ: heart. Organ: heart

Authors:

I.Vercellino,L.A.Sazanov

Key ref:

I.Vercellino and l.a.sazanov Structure and assembly of the mammalian mitochondrial supercomplex ciii 2 civ.. Nature, . PubMed id: 34616041

Date:

01-Apr-21 Release date: 13-Oct-21

Protein chains

Q9CZ13  (QCR1_MOUSE) -  Cytochrome b-c1 complex subunit 1, mitochondrial from Mus musculus

Seq: 480 a.a.

Struc: 446 a.a.

Protein chains

Q9DB77  (QCR2_MOUSE) -  Cytochrome b-c1 complex subunit 2, mitochondrial from Mus musculus

Seq: 453 a.a.

Struc: 420 a.a.

Protein chains

P00158  (CYB_MOUSE) -  Cytochrome b from Mus musculus

Seq: 381 a.a.

Struc: 379 a.a.

Protein chains

Q9D0M3  (CY1_MOUSE) -  Cytochrome c1, heme protein, mitochondrial from Mus musculus

Seq: 325 a.a.

Struc: 241 a.a.

Protein chains

Q9CR68  (UCRI_MOUSE) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial from Mus musculus

Seq: 274 a.a.

Struc: 196 a.a.

Protein chains

Q9D855  (QCR7_MOUSE) -  Cytochrome b-c1 complex subunit 7 from Mus musculus

Seq: 111 a.a.

Struc: 102 a.a.*

Protein chains

Q9CQ69  (QCR8_MOUSE) -  Cytochrome b-c1 complex subunit 8 from Mus musculus

Seq: 82 a.a.

Struc: 74 a.a.

Protein chains

P99028  (QCR6_MOUSE) -  Cytochrome b-c1 complex subunit 6, mitochondrial from Mus musculus

Seq: 89 a.a.

Struc: 68 a.a.

Protein chain

Q8R1I1  (QCR9_MOUSE) -  Cytochrome b-c1 complex subunit 9 from Mus musculus

Seq: 64 a.a.

Struc: 58 a.a.

Protein chains

Q9CPX8  (QCR10_MOUSE) -  Cytochrome b-c1 complex subunit 10 from Mus musculus

Seq: 56 a.a.

Struc: 52 a.a.

Protein chain

Q8R1I1  (QCR9_MOUSE) -  Cytochrome b-c1 complex subunit 9 from Mus musculus

Seq: 64 a.a.

Struc: 60 a.a.

Protein chain

Q9CR68  (UCRI_MOUSE) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial from Mus musculus

Seq: 274 a.a.

Struc: 78 a.a.

Protein chain

Q99KD6  (Q99KD6_MOUSE) -  Cox7a2l protein from Mus musculus

Seq: 113 a.a.

Struc: 111 a.a.

Protein chain

P00397  (COX1_MOUSE) -  Cytochrome c oxidase subunit 1 from Mus musculus

Seq: 514 a.a.

Struc: 514 a.a.

Protein chain

P00405  (COX2_MOUSE) -  Cytochrome c oxidase subunit 2 from Mus musculus

Seq: 227 a.a.

Struc: 227 a.a.

Protein chain

P00416  (COX3_MOUSE) -  Cytochrome c oxidase subunit 3 from Mus musculus

Seq: 261 a.a.

Struc: 259 a.a.

Protein chain

P19783  (COX41_MOUSE) -  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial from Mus musculus

Seq: 169 a.a.

Struc: 144 a.a.

Protein chain

P12787  (COX5A_MOUSE) -  Cytochrome c oxidase subunit 5A, mitochondrial from Mus musculus

Seq: 146 a.a.

Struc: 104 a.a.

Protein chain

P19536  (COX5B_MOUSE) -  Cytochrome c oxidase subunit 5B, mitochondrial from Mus musculus

Seq: 128 a.a.

Struc: 95 a.a.

Protein chain

P43023  (CX6A2_MOUSE) -  Cytochrome c oxidase subunit 6A2, mitochondrial from Mus musculus

Seq: 97 a.a.

Struc: 75 a.a.

Protein chain

P56391  (CX6B1_MOUSE) -  Cytochrome c oxidase subunit 6B1 from Mus musculus

Seq: 86 a.a.

Struc: 79 a.a.

Protein chain

Q9CPQ1  (COX6C_MOUSE) -  Cytochrome c oxidase subunit 6C from Mus musculus

Seq: 76 a.a.

Struc: 72 a.a.

Protein chain

P56393  (COX7B_MOUSE) -  Cytochrome c oxidase subunit 7B, mitochondrial from Mus musculus

Seq: 80 a.a.

Struc: 49 a.a.

Protein chain

P17665  (COX7C_MOUSE) -  Cytochrome c oxidase subunit 7C, mitochondrial from Mus musculus

Seq: 63 a.a.

Struc: 46 a.a.

Protein chain

P48772  (COX8B_MOUSE) -  Cytochrome c oxidase subunit 8B, mitochondrial from Mus musculus

Seq: 70 a.a.

Struc: 43 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: Chains D, E, O, P, T: E.C.7.1.1.8 - quinol--cytochrome-c reductase.
• Reaction: a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)- [cytochrome c](out) + 2 H(+)(out)
• Enzyme class 3: Chains a, b, c: E.C.7.1.1.9 - cytochrome-c oxidase.
• Reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H⁺(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H⁺(out)

4 × Fe(II)-[cytochrome c] (Bound ligand (Het Group name = HEM) matches with 63.64% similarity) + 2 × O2 + 8 × H(+)(in) = 4 × Fe(III)-[cytochrome c] + 2 × H2O + 4 × H(+)(out)

• Cofactor: Cu cation

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site