PDBsum entry 7o2w

Protein binding

PDB id: 7o2w

Contents

Protein chains

418 a.a.

422 a.a.

PDB id:

7o2w

Name:

Protein binding

Title:

Structure of the c9orf72-smcr8 complex

Structure:

Ubiquitin-like protein smt3,guanine nucleotide exchange c9orf72. Chain: a. Engineered: yes. Guanine nucleotide exchange protein smcr8,guanine nucleotide exchange protein smcr8,maltose/maltodextrin-binding periplasmic protein. Chain: b. Synonym: smith-magenis syndrome chromosomal region candidate gene 8

Source:

Saccharomyces cerevisiae s288c, homo sapiens. Baker's yeast, human. Organism_taxid: 559292, 9606. Gene: smt3, ydr510w, d9719.15, c9orf72. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens, escherichia coli k-12. Human. Organism_taxid: 9606, 83333.

Authors:

J.Noerpel,S.Cavadini,A.D.Schenk,A.Graff-Meyer,J.Chao,V.Bhaskar

Key ref:

J.Norpel et al. (2021). Structure of the human c9orf72-Smcr8 complex reveals multivalent protein interaction architecture.. Plos biol, 19, 01344. PubMed id: 34297726

Date:

31-Mar-21 Release date: 21-Jul-21

Protein chain

Q12306  (SMT3_YEAST) -  Ubiquitin-like protein SMT3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 101 a.a.

Struc: 418 a.a.*

Protein chain

Q96LT7  (CI072_HUMAN) -  Guanine nucleotide exchange factor C9orf72 from Homo sapiens

Seq: 481 a.a.

Struc: 418 a.a.

Protein chain

P0AEX9  (MALE_ECOLI) -  Maltose/maltodextrin-binding periplasmic protein from Escherichia coli (strain K12)

Seq: 396 a.a.

Struc: 422 a.a.*

Protein chain

Q8TEV9  (SMCR8_HUMAN) -  Guanine nucleotide exchange protein SMCR8 from Homo sapiens

Seq: 937 a.a.

Struc: 422 a.a.

* PDB and UniProt seqs differ at 418 residue positions (black crosses)