PDBsum entry 7o2f

Transferase

PDB id

7o2f

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Contents

			Protein chains

					203 a.a.


					244 a.a.

			Ligands

					UZ5


					ACT

			Waters ×217

PDB id:

7o2f

Links

Name:

Transferase

Title:

Crystal structure of the human mettl3-mettl14 complex bound to compound 22 (uzh2)

Structure:

N6-adenosine-methyltransferase catalytic subunit. Chain: a. Synonym: methyltransferase-like protein 3,hmettl3,n6-adenosine- methyltransferase 70 kda subunit,mt-a70. Engineered: yes. N6-adenosine-methyltransferase non-catalytic subunit. Chain: b. Synonym: methyltransferase-like protein 14,hmettl14. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mettl3, mta70. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mettl14, kiaa1627. Expression_system_taxid: 7108

Resolution:

2.10Å

R-factor:

0.199

R-free:

0.242

Authors:

R.K.Bedi,A.Dolbois,A.Caflisch

Key ref:

A.Dolbois et al. (2021). 1,4,9-Triazaspiro[5.5]undecan-2-One derivatives as po and selective mettl3 inhibitors.. J med chem, 64, 12738. PubMed id: 34431664

Date:

30-Mar-21

Release date:

01-Sep-21

PROCHECK

	Headers

	References

Protein chain

Q86U44 (MTA70_HUMAN) - N6-adenosine-methyltransferase catalytic subunit from Homo sapiens

Seq: Struc:

Seq: Struc:					580 a.a. 203 a.a.

Protein chain

Q9HCE5 (MET14_HUMAN) - N6-adenosine-methyltransferase non-catalytic subunit from Homo sapiens

Seq: Struc:					456 a.a. 244 a.a.

Key:

PfamA domain

Secondary structure



		Enzyme reactions

Enzyme class:

Chain A: E.C.2.1.1.348 - mRNA m(6)A methyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

an adenosine in mRNA + S-adenosyl-L-methionine = an N₆-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺

adenosine in mRNA	+	S-adenosyl-L-methionine	=	N(6)-methyladenosine in mRNA	+	S-adenosyl-L-homocysteine	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site