PDBsum entry 7nx1

Protein binding

PDB id: 7nx1

Contents

Protein chain

279 a.a.

Ligands

BTB ×2

Metals

_TB ×4

Waters ×173

PDB id:

7nx1

Name:

Protein binding

Title:

Tg domain of ltk

Structure:

Leukocyte tyrosine kinase receptor. Chain: a. Synonym: protein tyrosine kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ltk, tyk1. Expressed in: homo sapiens. Expression_system_taxid: 9606

Resolution:

1.30Å R-factor: 0.160 R-free: 0.181

Authors:

S.De Munck,S.N.Savvides

Key ref:

S.De munck et al. Structural basis of cytokine-Mediated activation of a family receptors.. Nature, . PubMed id: 34646012

Date:

17-Mar-21 Release date: 27-Oct-21

Protein chain

P29376  (LTK_HUMAN) -  Leukocyte tyrosine kinase receptor from Homo sapiens

Seq: 864 a.a.

Struc: 279 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site