PDBsum entry 7nqc

Signaling protein

PDB id: 7nqc

Contents

Protein chains

148 a.a.

18 a.a.

Ligands

ULW

Metals

_CA ×4

PDB id:

7nqc

Name:

Signaling protein

Title:

Calmodulin extracts the ras family protein rala from lipid bilayers by engagement with two membrane targeting motifs

Structure:

Calmodulin-1. Chain: a. Engineered: yes. Pro-asn-gly-lys-lys-lys-arg-lys-ser-leu-ala-lys-arg-ile- arg-glu-arg-cmf. Chain: b. Engineered: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: calm1, calm, cam, cam1, cami. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

NMR struc:

30 models

Authors:

S.G.Chamberlain,D.Owen,H.R.Mott

Key ref:

S.G.Chamberlain et al. (2021). Calmodulin extracts the ras family protein rala from bilayers by engagement with two membrane-Targeting mo. Proc natl acad sci usa, 118, . PubMed id: 34480001

Date:

01-Mar-21 Release date: 22-Sep-21

Protein chain

P0DP29  (CALM1_RAT) -  Calmodulin-1 from Rattus norvegicus

Seq: 149 a.a.

Struc: 148 a.a.

Protein chain

P11233  (RALA_HUMAN) -  Ras-related protein Ral-A from Homo sapiens

Seq: 206 a.a.

Struc: 18 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.2 - small monomeric GTPase.
• Reaction: GTP + H2O = GDP + phosphate + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site