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PDBsum entry 7nlp
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PDB id:
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Transferase
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Title:
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Crystal structure of mycobacterium tuberculosis argb in complex with l-canavanine
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Structure:
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Acetylglutamate kinase. Chain: a. Synonym: n-acetyl-l-glutamate 5-phosphotransferase,NAG kinase,nagk. Engineered: yes
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Source:
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Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Gene: argb, rv1654, mtcy06h11.19. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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2.21Å
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R-factor:
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0.207
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R-free:
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0.241
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Authors:
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V.Mendes,S.E.Thomas,J.Cory-Wright,T.L.Blundell
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Key ref:
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P.Gupta
et al.
(2021).
A fragment-Based approach to assess the ligandability argb, Argc, Argd and argf in the l-Arginine biosynthe pathway of mycobacterium tuberculosis.
Comput struct biotechnol j,
19,
3491.
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Date:
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22-Feb-21
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Release date:
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30-Jun-21
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PROCHECK
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Headers
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References
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P9WQ01
(ARGB_MYCTU) -
Acetylglutamate kinase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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Seq:
Struc:
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294 a.a.
292 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.2.8
- acetylglutamate kinase.
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Pathway:
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Ornithine Biosynthesis
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Reaction:
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N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP
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N-acetyl-L-glutamate
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+
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ATP
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=
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N-acetyl-L-glutamyl 5-phosphate
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+
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ADP
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
