PDBsum entry 7mo8

Signaling protein

PDB id: 7mo8

Contents

Protein chains

637 a.a.

613 a.a.

Ligands

SGN-IDS-SGN-IDS-SGN-IDS

PDB id:

7mo8

Name:

Signaling protein

Title:

Cryo-em structure of 1:1 c-met i/hgf i complex after focused 3d refinement of holo-complex

Structure:

Hepatocyte growth factor. Chain: a. Synonym: hepatopoietin-a,scatter factor,sf. Engineered: yes. Hepatocyte growth factor receptor. Chain: b. Synonym: hgf receptor,hgf/sf receptor,proto-oncogenE C-met,scatter factor receptor,sf receptor,tyrosine-protein kinase met. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: met. Expression_system_taxid: 9606

Authors:

E.Uchikawa,Z.M.Chen,G.Y.Xiao,X.W.Zhang,X.C.Bai

Key ref:

E.Uchikawa et al. Structural basis of the activation of c-Met receptor. To be published, . PubMed id: 34210960

Date:

01-May-21 Release date: 09-Jun-21

Protein chain

P14210  (HGF_HUMAN) -  Hepatocyte growth factor from Homo sapiens

Seq: 728 a.a.

Struc: 637 a.a.

Protein chain

P08581  (MET_HUMAN) -  Hepatocyte growth factor receptor from Homo sapiens

Seq: 1390 a.a.

Struc: 613 a.a.

Enzyme reactions

• Enzyme class: Chain B: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site