PDBsum entry 7mo2

Transport protein

PDB id: 7mo2

Contents

Protein chains

201 a.a.

38 a.a.

Ligands

GDP ×2

Metals

_MG ×2

_ZN ×2

Waters ×429

PDB id:

7mo2

Name:

Transport protein

Title:

Crystal structure of the znf2 of nucleoporin nup153 in complex with ran-gdp

Structure:

Gtp-binding nuclear protein ran. Chain: a, c. Synonym: androgen receptor-associated protein 24,gtpase ran,ras-like protein tc4,ras-related nuclear protein. Engineered: yes. Mutation: yes. Nuclear pore complex protein nup153. Chain: b, d. Fragment: zinc finger 2 of nup153 (unp residues 713-749).

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ran, ara24, ok/sw-cl.81. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Rat. Organism_taxid: 10116.

Resolution:

1.65Å R-factor: 0.213 R-free: 0.241

Authors:

C.J.Bley,S.Nie,G.W.Mobbs,S.Petrovic,A.T.Gres,X.Liu,S.Mukherjee, S.Harvey,F.M.Huber,D.H.Lin,B.Brown,A.W.Tang,E.J.Rundlet,A.R.Correia, S.Chen,S.G.Regmi,T.A.Stevens,C.A.Jette,M.Dasso,A.Patke,A.F.Palazzo, A.A.Kossiakoff,A.Hoelz

Key ref:

C.J.Bley et al. (2022). Architecture of the cytoplasmic face of the nuclear p. Science, 376, . PubMed id: 35679405

Date:

01-May-21 Release date: 15-Jun-22

Protein chains

P62826  (RAN_HUMAN) -  GTP-binding nuclear protein Ran from Homo sapiens

Seq: 216 a.a.

Struc: 201 a.a.*

Protein chains

P49791  (NU153_RAT) -  Nuclear pore complex protein Nup153 from Rattus norvegicus

Seq: 1468 a.a.

Struc: 38 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: Chains A, C: E.C.3.6.5.- - ?????
• Enzyme class 2: Chains B, D: E.C.?

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.