PDBsum entry 7mkc

Viral protein

PDB id: 7mkc

Contents

Protein chain

221 a.a.

Ligands

1B0

Metals

IOD ×6

Waters ×16

PDB id:

7mkc

Name:

Viral protein

Title:

N74d mutant of the HIV-1 capsid protein in complex with pf-3450074 (pf74)

Structure:

Capsid protein. Chain: a. Synonym: gag polyprotein. Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3. Gene: gag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: ril.

Resolution:

2.65Å R-factor: 0.186 R-free: 0.242

Authors:

K.A.Kirby,S.G.Sarafianos

Key ref:

A.Selyutina et al. (2022). Trim5alpha restriction of HIV-1-N74d viruses in lymph is caused by a loss of cyclophilin a protection.. Viruses, 14, 363. PubMed id: 35215956

Date:

23-Apr-21 Release date: 04-May-22

Protein chain

P12493  (GAG_HV1N5) -  Gag polyprotein from Human immunodeficiency virus type 1 group M subtype B (isolate NY5)

Seq: 500 a.a.

Struc: 221 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)