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PDBsum entry 7mfc
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Transferase/transferase inhibitor
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PDB id
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7mfc
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Crystal structure of csf1r in complex with vimseltinib
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Structure:
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Macrophage colony-stimulating factor 1 receptor. Chain: a. Fragment: kinase domain, unp residues 542-919 with deletion of 696- 741. Synonym: csf-1 receptor,csf-1-r,csf-1r,m-csf-r,proto-oncogenE C-fms. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
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Resolution:
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2.80Å
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R-factor:
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0.229
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R-free:
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0.256
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Authors:
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J.Abendroth,D.R.Davies,K.Atkins
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Key ref:
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B.D.Smith
et al.
(2021).
Vimseltinib: a precision csf1r therapy for tenosynovi giant cell tumors and diseases promoted by macrophage.
Mol cancer ther,
20,
2098.
PubMed id:
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Date:
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08-Apr-21
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Release date:
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24-Nov-21
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PROCHECK
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Headers
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References
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P07333
(CSF1R_HUMAN) -
Macrophage colony-stimulating factor 1 receptor from Homo sapiens
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Seq:
Struc:
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972 a.a.
287 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
