PDBsum entry 7mbh

Lyase

PDB id: 7mbh

Contents

Protein chains

436 a.a.

Ligands

PO4

ACT

EDO ×3

PGE

SEP

Metals

_MG ×2

Waters ×298

PDB id:

7mbh

Name:

Lyase

Title:

Structure of human enolase 2 in complex with phosphoserine

Structure:

Gamma-enolase. Chain: a, b. Synonym: 2-phospho-d-glycerate hydro-lyase, enolase 2, neural enolase, neuron-specific enolase, nse. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eno2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.10Å R-factor: 0.183 R-free: 0.235

Authors:

P.G.Leonard,K.G.Hicks,J.Rutter

Key ref:

K.G.Hick et al. The protein-Metabolite interactome of central carbon metabolism reveals novel regulation of pyruvate metab. To be published, . PubMed id: 36893255

Date:

31-Mar-21 Release date: 09-Nov-22

Protein chains

P09104  (ENOG_HUMAN) -  Gamma-enolase from Homo sapiens

Seq: 434 a.a.

Struc: 436 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.11 - phosphopyruvate hydratase.
• Reaction: (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O

(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O (Bound ligand (Het Group name = SEP) matches with 50.00% similarity)

• Cofactor: Mg(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site