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PDBsum entry 7m1h
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protein metals Protein-protein interface(s) links
Antitoxin PDB id
7m1h

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
430 a.a.
123 a.a.
117 a.a.
123 a.a.
123 a.a.
121 a.a.
104 a.a.
Metals
_ZN
Waters ×50
PDB id:
7m1h
Name: Antitoxin
Title: Crystal structure of lc/a-jpu-c10-jpu-d12-jpu-b8-jpu-g3-cia-f12-cia- d12
Structure: Botulinum neurotoxin a light chain. Chain: a. Synonym: lc. Engineered: yes. Jpu-d12. Chain: b. Engineered: yes. Cia-f12. Chain: c.
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bont. Expressed in: escherichia coli. Expression_system_taxid: 562. Vicugna pacos. Organism_taxid: 30538. Expression_system_taxid: 562
Resolution:
2.78Å     R-factor:   0.218     R-free:   0.249
Authors: K.Lam,R.Jin
Key ref: K.H.Lam et al. (2022). Probing the structure and function of the protease do botulinum neurotoxins using single-Domain antibodies.. Plos pathog, 18, 10169. PubMed id: 34990480
Date:
13-Mar-21     Release date:   22-Dec-21    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P0DPI0  (BXA1_CLOBO) -  Botulinum neurotoxin type A from Clostridium botulinum
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1296 a.a.
430 a.a.
Protein chain
No UniProt id for this chain
Struc: 123 a.a.
Protein chain
No UniProt id for this chain
Struc: 117 a.a.
Protein chain
No UniProt id for this chain
Struc: 123 a.a.
Protein chain
No UniProt id for this chain
Struc: 123 a.a.
Protein chain
No UniProt id for this chain
Struc: 121 a.a.
Protein chain
No UniProt id for this chain
Struc: 104 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: Chain A: E.C.3.4.24.69  - bontoxilysin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
      Cofactor: Zn(2+)

 

 

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