PDBsum entry 7lpy

Hydrolase

PDB id: 7lpy

Contents

Protein chains

200 a.a.

Ligands

AMP ×2

GOL

Metals

_MN ×4

Waters ×158

PDB id:

7lpy

Name:

Hydrolase

Title:

Crystal structures and ribonuclease activity of the flavivirus host factor eri3 that is involved in viral RNA synthesis define the eri subfamily of structure-specific 3-prime - 5-prime exoribonucleases

Structure:

Eri1 exoribonuclease 3. Chain: a, b. Synonym: prion interactor 1,prion protein-interacting protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eri3, pint1, prnpip, prnpip1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.85Å R-factor: 0.180 R-free: 0.205

Authors:

R.Thapar,A.S.Andrew,J.A.Tainer

Key ref:

R.Thapar et al. Crystal structures and ribonuclease activity of the flavivirus host factor eri3 that is involved in viral synthesis define the eri subfamily of structure-Speci - 5' Exoribonucleases. To be published, .

Date:

12-Feb-21 Release date: 16-Feb-22

Protein chains

O43414  (ERI3_HUMAN) -  ERI1 exoribonuclease 3 from Homo sapiens

Seq: 337 a.a.

Struc: 200 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.-.-