PDBsum entry 7lfc

Protein transport

PDB id: 7lfc

Contents

Protein chains

414 a.a.

12 a.a.

Waters ×105

PDB id:

7lfc

Name:

Protein transport

Title:

Structure of importin a3 bound to p50 nls

Structure:

Importin subunit alpha-3. Chain: a. Synonym: importin alpha q1,qip1,karyopherin subunit alpha-4. Engineered: yes. Nuclear factor nf-kappa-b p105 subunit. Chain: b. Fragment: nuclear localization signal motif, residues 355-368. Synonym: DNA-binding factor kbf1,ebp-1,nuclear factor of kappa light polypeptide gene enhancer in b-cells 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kpna4, qip1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.10Å R-factor: 0.189 R-free: 0.220

Authors:

T.J.Florio,R.K.Lokareddy,G.Cingolani

Key ref:

T.J.Florio et al. A trans bipartite nls mediates nuclear translocation canonical nf-Kb p65:p50 heterodimer. To be published, . PubMed id: 35260573

Date:

16-Jan-21 Release date: 19-Jan-22

Protein chain

O00629  (IMA3_HUMAN) -  Importin subunit alpha-3 from Homo sapiens

Seq: 521 a.a.

Struc: 414 a.a.

Protein chain

P19838  (NFKB1_HUMAN) -  Nuclear factor NF-kappa-B p105 subunit from Homo sapiens

Seq: 968 a.a.

Struc: 12 a.a.