PDBsum entry 7l4x

DNA binding protein/DNA

PDB id: 7l4x

Contents

Protein chain

165 a.a.

DNA/RNA

Ligands

EDO ×3

Waters ×103

PDB id:

7l4x

Name:

DNA binding protein/DNA

Title:

Yth domain of human ythdc1 with dsdna comprising single n6ma joined by two six-bp DNA duplexes in p3221 crystal

Structure:

Yth domain-containing protein 1. Chain: b. Synonym: splicing factor yt521,yt521-b. Engineered: yes. Ssdna w/n6a. Chain: e. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ythdc1, kiaa1966, yt521. Expressed in: escherichia coli. Expression_system_taxid: 866768. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

1.79Å R-factor: 0.200 R-free: 0.232

Authors:

J.R.Horton,X.Cheng

Key ref:

D.Yu et al. Human mettl3-Mettl14 RNA adenine methyltransferase co is active on double-Stranded DNA containing lesions.. Nucleic acids res, . PubMed id: 34086966

Date:

21-Dec-20 Release date: 03-Nov-21

Protein chain

Q96MU7  (YTDC1_HUMAN) -  YTH domain-containing protein 1 from Homo sapiens

Seq: 727 a.a.

Struc: 165 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DNA/RNA chain

C-A-G-C-T-G-6MA-G-T-C-G-A-C 13 bases