PDBsum entry 7l1d

Immune system

PDB id: 7l1d

Contents

Protein chains

274 a.a.

99 a.a.

187 a.a.

247 a.a.

Ligands

ALA-LEU-HIS-GLY-GLY-TRP-THR-THR-LYS

ACT

GOL

PDB id:

7l1d

Name:

Immune system

Title:

Crystal structure of human 21lt2-2 tcr bound to hla-a 03:01 In complex with a mutant pik3ca peptide

Structure:

Hla class i histocompatibility antigen, a alpha chain. Chain: a. Synonym: human leukocyte antigen a,hla-a. Engineered: yes. Beta-2-microglobulin. Chain: b. Engineered: yes. Mutant pik3ca peptide. Chain: c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes. Expression_system_taxid: 562

Resolution:

3.11Å R-factor: 0.202 R-free: 0.250

Authors:

J.Ma,B.M.Baker

Key ref:

j.ma and b.m.baker (2022). Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med, 0, . PubMed id: 35484264

Date:

14-Dec-20 Release date: 23-Mar-22

Protein chain

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 274 a.a.

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 99 a.a.

Protein chain

No UniProt id for this chain

Struc: 187 a.a.

Protein chain

No UniProt id for this chain

Struc: 247 a.a.

Nat Med 0: (2022)

PubMed id: 35484264

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.

j.ma, b.m.baker.

ABSTRACT

No abstract given.