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PDBsum entry 7kpm
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PDB id:
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Transferase
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Title:
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Crystal structure of hephb1 bound with adp
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Structure:
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Ephrin type-b receptor 1. Chain: a. Synonym: elk,eph tyrosine kinase 2,eph-like kinase 6,hek6,neuronally- expressed eph-related tyrosine kinase,net,tyrosine-protein kinase receptor eph-2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, elk, epht2, hek6, net. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.61Å
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R-factor:
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0.169
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R-free:
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0.197
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Authors:
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M.Ahmed,P.Wang,H.Sadek
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Key ref:
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m.ahmed
et al.
(2021).
Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
Proc.Natl.Acad.Sci.USA,
118,
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PubMed id:
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Date:
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11-Nov-20
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Release date:
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10-Mar-21
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PROCHECK
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Headers
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References
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P54762
(EPHB1_HUMAN) -
Ephrin type-B receptor 1 from Homo sapiens
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Seq:
Struc:
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984 a.a.
255 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
Bound ligand (Het Group name = )
corresponds exactly
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Proc.Natl.Acad.Sci.USA
118:
(2021)
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PubMed id:
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Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
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m.ahmed,
p.wang,
y.nakada,
i.menendez-montes,
m.ismail,
m.henkemeyer,
h.sadek,
e.kandil.
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ABSTRACT
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