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PDBsum entry 7kpe
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PDB id:
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| Name: |
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Lyase
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Title:
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Dihydrodipicolinate synthase (dhdps) from c.Jejuni, e88q mutant with pyruvate bound in the active site and r,r-bislysine at the allosteric site
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Structure:
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4-hydroxy-tetrahydrodipicolinate synthase. Chain: a, b, c, d, e, f. Synonym: htpa synthase. Engineered: yes. Mutation: yes
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Source:
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Campylobacter jejuni subsp. Jejuni serotype o:2 (strain atcc 700819 / nctc 11168). Organism_taxid: 192222. Strain: atcc 700819 / nctc 11168. Gene: dapa, cj0806. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.06Å
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R-factor:
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0.202
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R-free:
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0.241
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Authors:
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S.Saran,D.A.R.Sanders
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Key ref:
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S.Saran
et al.
The allosteric site residue, E88 interacts with the inhibitors to transmit the allosteric inhibition sign cj.Dhdps by forming a hydrogen bond..
To be published,
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Date:
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11-Nov-20
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Release date:
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17-Nov-21
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PROCHECK
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Headers
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References
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Q9PPB4
(DAPA_CAMJE) -
4-hydroxy-tetrahydrodipicolinate synthase from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
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Seq:
Struc:
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298 a.a.
296 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.4.3.3.7
- 4-hydroxy-tetrahydrodipicolinate synthase.
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Reaction:
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L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate + H2O + H+
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L-aspartate 4-semialdehyde
Bound ligand (Het Group name = )
matches with 50.00% similarity
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+
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pyruvate
Bound ligand (Het Group name = )
matches with 71.43% similarity
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=
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(2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate
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+
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H2O
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
