PDBsum entry 7kd7

Transferase

PDB id: 7kd7

Contents

Protein chains

202 a.a.

Ligands

SER-GLY-ARG-GLY-LYS ×2

GOL ×4

SO4 ×4

BTB

CMC ×2

NH2 ×2

Waters ×369

PDB id:

7kd7

Name:

Transferase

Title:

Crystal structure of human natd (naa40) bound to a bisubstrate analogue

Structure:

N-alpha-acetyltransferase 40. Chain: d, a. Synonym: n-acetyltransferase 11,n-alpha-acetyltransferase d,hnatd, protein acetyltransferase 1. Engineered: yes. Ser-gly-arg-gly-lys. Chain: e, b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: naa40, nat11, patt1. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.44Å R-factor: 0.163 R-free: 0.183

Authors:

S.Deng,R.Marmorstein

Key ref:

S.Deng and r.marmorstein Crystal structure of human natd (naa40) bound to a bisubstrate analogue. To be published, . PubMed id: 34110812

Date:

08-Oct-20 Release date: 16-Jun-21

Protein chains

Q86UY6  (NAA40_HUMAN) -  N-alpha-acetyltransferase 40 from Homo sapiens

Seq: 237 a.a.

Struc: 202 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.1.257 - N-terminal L-serine N(alpha)-acetyltransferase NatD.
• Reaction:
  1. N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)- acetyl-L-seryl-[histone H4] + CoA + H⁺
  2. N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)- acetyl-L-seryl-[histone H2A] + CoA + H⁺

N-terminal L-seryl-[histone H4] (Bound ligand (Het Group name = CMC) matches with 96.15% similarity) + acetyl-CoA = N-terminal N(alpha)- acetyl-L-seryl-[histone H4] + CoA + H(+)

N-terminal L-seryl-[histone H2A] (Bound ligand (Het Group name = CMC) matches with 96.15% similarity) + acetyl-CoA = N-terminal N(alpha)- acetyl-L-seryl-[histone H2A] + CoA + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site