PDBsum entry 7kd2

Toxin

PDB id: 7kd2

Contents

Protein chains

258 a.a.

261 a.a.

115 a.a.

Ligands

NAG-FUC

NAG-NAG

NAG-NAG-BMA

Metals

_CL ×8

_ZN ×5

Waters ×182

PDB id:

7kd2

Name:

Toxin

Title:

Ricin bound to vhh antibody v11b2

Structure:

Ricin chain a. Chain: a. Other_details: glycosidase. Ricin chain b. Chain: b. Other_details: lectin. Vhh antibody v11b2. Chain: c. Engineered: yes.

Source:

Ricinus communis. Castor bean. Organism_taxid: 3988. Vicugna pacos. Organism_taxid: 30538. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.55Å R-factor: 0.229 R-free: 0.280

Authors:

M.J.Rudolph

Key ref:

M.J.Rudolph et al. (2021). Structural analysis of toxin-Neutralizing, Single-Dom antibodies that bridge ricin'S a-B subunit interface.. J mol biol, 433, 67086. PubMed id: 34089718

Date:

07-Oct-20 Release date: 04-Aug-21

Protein chain

P02879  (RICI_RICCO) -  Ricin from Ricinus communis

Seq: 576 a.a.

Struc: 258 a.a.

Protein chain

P02879  (RICI_RICCO) -  Ricin from Ricinus communis

Seq: 576 a.a.

Struc: 261 a.a.

Protein chain

No UniProt id for this chain

Struc: 115 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.2.2.22 - rRNA N-glycosylase.
• Reaction: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.