PDBsum entry 7hgo

Gene regulation

PDB id: 7hgo

Contents

Protein chains

93 a.a.

88 a.a.

Ligands

SO4 ×6

EDO ×2

8DH

Waters ×272

PDB id:

7hgo

Name:

Gene regulation

Title:

Pandda analysis group deposition -- crystal structure of hrp-2 pwwp domain in complex with z431807512

Structure:

Hepatoma-derived growth factor-related protein 2. Chain: a, b, c. Synonym: hdgf-related protein 2,hrp-2,hepatoma-derived growth factor 2,hdgf-2. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hdgfl2, hdgf2, hdgfrp2, hrp2, unq785/pro1604. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.44Å R-factor: 0.208 R-free: 0.236

Authors:

T.Vantieghem,E.Osipov,D.Fearon,A.Douangamath,F.Von Delft,S.Strelkov

Key ref:

T.Vantieghem et al. (2024). Rational fragment-Based design of compounds targeting pwwp domain of the hrp family.. Eur j med chem, 280, 16960. PubMed id: 39461037

Date:

29-Aug-24 Release date: 06-Nov-24

Protein chain

Q7Z4V5  (HDGR2_HUMAN) -  Hepatoma-derived growth factor-related protein 2 from Homo sapiens

Seq: 671 a.a.

Struc: 93 a.a.*

Protein chains

Q7Z4V5  (HDGR2_HUMAN) -  Hepatoma-derived growth factor-related protein 2 from Homo sapiens

Seq: 671 a.a.

Struc: 88 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)