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PDBsum entry 7hap
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PDB id:
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Chaperone
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Title:
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Pandda analysis group deposition -- crystal structure of hsp90n in complex with fr13088
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Structure:
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Heat shock protein hsp 90-alpha. Chain: a. Synonym: heat shock 86 kda,hsp 86,hsp86,heat shock protein family c member 1,lipopolysaccharide-associated protein 2,lap-2,lps-associated protein 2,renal carcinoma antigen ny-ren-38. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hsp90aa1, hsp90a, hspc1, hspca. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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2.35Å
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R-factor:
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0.206
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R-free:
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0.248
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Authors:
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L.Huang,W.Wang,Z.Zhu,Q.Li,M.Li,H.Zhou,Q.Xu,W.Wen,Q.Wang,F.Yu
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Key ref:
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L.Huang
et al.
(2025).
Novel starting points for fragment-Based drug design human heat-Shock protein 90 identified using crystallographic fragment screening..
Iucrj,
12,
177.
PubMed id:
DOI:
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Date:
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10-Jul-24
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Release date:
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26-Mar-25
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PROCHECK
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Headers
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References
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P07900
(HS90A_HUMAN) -
Heat shock protein HSP 90-alpha from Homo sapiens
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Seq:
Struc:
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732 a.a.
209 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.3.6.4.10
- non-chaperonin molecular chaperone ATPase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
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+
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
