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PDBsum entry 7h3c
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PDB id:
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Hydrolase
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Title:
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Group deposition for crystallographic fragment screening of coxsackievirus a16 (g-10) 2a protease -- crystal structure of coxsackievirus a16 (g-10) 2a protease in complex with z54750053 (a71ev2a-x0359)
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Structure:
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Protease 2a. Chain: a. Synonym: p2a,picornain 2a,protein 2a. Engineered: yes
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Source:
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Coxsackievirus a16. Organism_taxid: 31704. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.07Å
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R-factor:
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0.163
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R-free:
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0.175
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Authors:
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R.M.Lithgo,M.Fairhead,L.Koekemoer,B.H.Balcomb,E.Capkin,A.V.Chandran, M.Golding,A.S.Godoy,J.C.Aschenbrenner,P.G.Marples,X.Ni,W.Thompson, C.W.E.Tomlinson,C.Wild,M.Winokan,M.-A.E.Xavier,D.Fearon,F.Von Delft
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Key ref:
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R.M.Lithgo
et al.
Group deposition for crystallographic fragment screen coxsackievirus a16 (g-10) 2a protease.
To be published,
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PubMed id:
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Date:
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04-Apr-24
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Release date:
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24-Apr-24
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PROCHECK
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Headers
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References
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Q65900
(POLG_CX16G) -
Genome polyprotein from Coxsackievirus A16 (strain G-10)
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Seq:
Struc:
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2193 a.a.
140 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class 2:
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E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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E.C.3.4.22.28
- picornain 3C.
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Reaction:
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 4:
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E.C.3.4.22.29
- picornain 2A.
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Reaction:
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 5:
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E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
