PDBsum entry 7gmh

Viral protein

PDB id: 7gmh

Contents

Protein chains

305 a.a.

Ligands

DMS ×10

RJX ×2

Metals

_CL

Waters ×406

PDB id:

7gmh

Name:

Viral protein

Title:

Group deposition sars-cov-2 main protease in complex with inhibitors from the covid moonshot -- crystal structure of sars-cov-2 main protease in complex with mat-pos-90fd5f68-37 (mpro-p2183)

Structure:

3c-like proteinase. Chain: a, b. Synonym: 3cl-pro, 3clp, main protease, mpro, non-structural protein 5, nsp5, sars coronavirus main proteinase. Engineered: yes

Source:

Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049. Gene: rep, 1a-1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.85Å R-factor: 0.213 R-free: 0.236

Authors:

D.Fearon,A.Aimon,J.C.Aschenbrenner,B.H.Balcomb,F.K.R.Bertram, J.Brandao-Neto,A.Dias,A.Douangamath,L.Dunnett,A.S.Godoy,T.J.Gorrie- Stone,L.Koekemoer,T.Krojer,R.M.Lithgo,P.Lukacik,P.G.Marples, H.Mikolajek,E.Nelson,C.D.Owen,A.J.Powell,V.L.Rangel,R.Skyner, C.M.Strain-Damerell,W.Thompson,C.W.E.Tomlinson,C.Wild,M.A.Walsh, F.Von Delft

Key ref:

M.L.Boby et al. Open science discovery of potent noncovalent sars-Cov protease inhibitors. Science, . PubMed id: 37943932

Date:

11-Aug-23 Release date: 08-Nov-23

Protein chains

P0DTD1  (R1AB_SARS2) -

Enzyme reactions

• Enzyme class: E.C.3.4.22.69 - Sars coronavirus main proteinase.