PDBsum entry 7g4z

Hydrolase

PDB id: 7g4z

Contents

Protein chain

806 a.a.

Ligands

NAG-NAG-BMA-MAN-MAN-MAN-MAN-MAN

Metals

_CL

_CA ×2

_NA ×2

Waters ×629

PDB id:

7g4z

Name:

Hydrolase

Title:

Crystal structure of rat apo autotaxin

Structure:

Isoform 2 of ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Chain: a. Fragment: residues 1-862. Synonym: e-npp 2,autotaxin,extracellular lysophospholipase d,lysopld. Engineered: yes. Mutation: yes

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: enpp2, atx, npps2. Expressed in: homo sapiens. Expression_system_taxid: 9606.

Resolution:

1.55Å R-factor: 0.180 R-free: 0.218

Authors:

M.Stihle,J.Benz,D.Hunziker,M.G.Rudolph

Key ref:

D.Hunziker et al. Crystal structure of rat apo autotaxin without zinc. To be published, .

Date:

05-Jun-23 Release date: 18-Dec-24

Protein chain

Q64610  (ENPP2_RAT) -  Autotaxin from Rattus norvegicus

Seq: 887 a.a.

Struc: 806 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase.
• Reaction: a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl- sn-glycero-3-phosphate + ethanolamine + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site