PDBsum entry 7g0c

Lipid binding protein

PDB id: 7g0c

Contents

Protein chain

130 a.a.

Ligands

WA9

Waters ×171

PDB id:

7g0c

Name:

Lipid binding protein

Title:

Crystal structure of human fabp4 binding site mutated to that of fabp5 in complex with 2-[2,3-bis[(2-chlorophenyl)methoxy]phenyl]-2- methoxyacetic acid, i.E. Smiles c1c(c(c(cc1)occ1ccccc1cl) occ1c(cccc1)cl)[c@@h](c(=o)o)oc with ic50=1.1 microm

Structure:

Fatty acid-binding protein, adipocyte. Chain: a. Synonym: adipocyte lipid-binding protein,albp,adipocyte-type fatty acid-binding protein,a-fabp,afabp,fatty acid-binding protein 4. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fabp4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.14Å R-factor: 0.168 R-free: 0.213

Authors:

A.Ehler,J.Benz,U.Obst,U.Obst-Sander,M.G.Rudolph

Key ref:

U.Obst et al. Crystal structure of a human fabp4 binding site mutat that of fabp5 complex. To be published, . PubMed id: 40748031

Date:

27-Apr-23 Release date: 14-Jun-23

Protein chain

P15090  (FABP4_HUMAN) -  Fatty acid-binding protein, adipocyte from Homo sapiens

Seq: 132 a.a.

Struc: 130 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)