PDBsum entry 7fxh

Lipid binding protein

PDB id: 7fxh

Contents

Protein chain

134 a.a.

Ligands

RI4

FMT ×4

DMS ×2

SO4 ×2

Waters ×155

PDB id:

7fxh

Name:

Lipid binding protein

Title:

Crystal structure of human fabp4 in complex with 2-[(2r)-oxolan-2-yl]- 4-phenyl-3-(1h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h- cyclohepta[b]pyridine, i.E. Smiles c1(c(c(c2c(n1)ccccc2)c1ccccc1) c1=nn=nn1)[c@h]1ccco1 with ic50=0.0496937 microm

Structure:

Fatty acid-binding protein, adipocyte. Chain: a. Synonym: adipocyte lipid-binding protein,albp,adipocyte-type fatty acid-binding protein,a-fabp,afabp,fatty acid-binding protein 4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fabp4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.02Å R-factor: 0.139 R-free: 0.160

Authors:

A.Ehler,J.Benz,U.Obst,U.Obst-Sander,M.G.Rudolph

Key ref:

U.Obst et al. Crystal structure of a human fabp4 complex. To be published, . PubMed id: 40748031

Date:

27-Apr-23 Release date: 14-Jun-23

Protein chain

P15090  (FABP4_HUMAN) -  Fatty acid-binding protein, adipocyte from Homo sapiens

Seq: 132 a.a.

Struc: 134 a.a.