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PDBsum entry 7fql
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PDB id:
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Hydrolase
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Title:
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Crystal structure of human legumain in complex with (2s)-n-[(1s)-3- amino-1-cyano-3-oxopropyl]-1-[1-[4-[(2,4-difluorophenyl) methoxy]phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide
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Structure:
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Legumain. Chain: a, b, c, d, e, f, g, h. Synonym: asparaginyl endopeptidase,protease,cysteine 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: lgmn, prsc1. Expressed in: drosophila melanogaster. Expression_system_taxid: 7215.
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Resolution:
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2.53Å
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R-factor:
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0.195
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R-free:
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0.252
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Authors:
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A.Ehler,J.Benz,B.Bartels,M.G.Rudolph
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Key ref:
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B.Bartels
et al.
Crystal structure of a human legumain complex.
To be published,
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Date:
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05-Oct-22
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Release date:
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11-Oct-23
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PROCHECK
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Headers
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References
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Q99538
(LGMN_HUMAN) -
Legumain from Homo sapiens
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Seq:
Struc:
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433 a.a.
260 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.4.22.34
- legumain.
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Reaction:
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Hydrolysis of proteins and small-molecule substrates at -Asn-|-Xaa- bonds.
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Links
