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PDBsum entry 7fqc
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Oxidoreductase
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PDB id
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7fqc
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Dhfr:nadp+:fol complex (crystal 2, pass 1, 295 k)
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Structure:
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Dihydrofolate reductase. Chain: a. Engineered: yes
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Source:
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Escherichia coli k-12. Organism_taxid: 83333. Strain: k12. Gene: fola, tmra, b0048, jw0047. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.18Å
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R-factor:
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0.129
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R-free:
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0.160
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Authors:
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J.B.Greisman,K.M.Dalton,D.E.Brookner,D.R.Hekstra
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Key ref:
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J.B.Greisman
et al.
Single-Crystal, Multi-Temperature experiment of dhfr:NADP+:fol complex.
To be published,
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PubMed id:
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Date:
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12-Sep-22
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Release date:
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20-Sep-23
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PROCHECK
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Headers
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References
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P0ABQ4
(DYR_ECOLI) -
Dihydrofolate reductase from Escherichia coli (strain K12)
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Seq:
Struc:
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159 a.a.
159 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.1.5.1.3
- dihydrofolate reductase.
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Pathway:
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Folate Coenzymes
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Reaction:
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(6S)-5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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(6S)-5,6,7,8-tetrahydrofolate
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+
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NADP(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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7,8-dihydrofolate
Bound ligand (Het Group name = )
corresponds exactly
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+
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NADPH
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
