PDBsum entry 7feh

Transferase

PDB id: 7feh

Contents

Protein chain

293 a.a.

Ligands

3UI

NO3 ×2

Waters ×226

PDB id:

7feh

Name:

Transferase

Title:

Crystal structure of human ddr1 in complex with ch5541127

Structure:

Epithelial discoidin domain-containing receptor 1. Chain: a. Fragment: residues: 593-913. Engineered: yes. Other_details: del:730-735

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.61Å R-factor: 0.168 R-free: 0.206

Authors:

T.A.Fukami,S.Kadono,T.Matsuura

Key ref:

T.A.Fukami et al. Novel potent and highly selective ddr1 inhibitors fro structure-Guided drug design. To be published, .

Date:

20-Jul-21 Release date: 27-Jul-22

Protein chain

Q08345  (DDR1_HUMAN) -  Epithelial discoidin domain-containing receptor 1 from Homo sapiens

Seq: 913 a.a.

Struc: 293 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site