PDBsum entry 7faq

Hydrolase/inhibitor

PDB id: 7faq

Contents

Protein chain

287 a.a.

Ligands

SO4-2OI

Metals

_ZN

_MG

Waters ×72

PDB id:

7faq

Name:

Hydrolase/inhibitor

Title:

Crystal structure of pde5a in complex with inhibitor l1

Structure:

Cgmp-specific 3',5'-cyclic phosphodiesterase. Chain: a. Synonym: cgmp-binding cgmp-specific phosphodiesterase,cgb-pde. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5a, pde5. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

2.20Å R-factor: 0.228 R-free: 0.272

Authors:

D.Wu,Y.Y.Huang,H.B.Luo

Key ref:

D.Wu et al. (2022). Free energy perturbation (fep)-Guided scaffold hoppin. Acta pharm sin b, 12, 1351. PubMed id: 35530128

Date:

07-Jul-21 Release date: 18-May-22

Protein chain

O76074  (PDE5A_HUMAN) -  cGMP-specific 3',5'-cyclic phosphodiesterase from Homo sapiens

Seq: 875 a.a.

Struc: 287 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase.
• Reaction: 3',5'-cyclic GMP + H2O = GMP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site