PDBsum entry 7f6h

Membrane protein

PDB id: 7f6h

Contents

Protein chains

305 a.a.

226 a.a.

330 a.a.

47 a.a.

Ligands

ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG

CLR ×2

PDB id:

7f6h

Name:

Membrane protein

Title:

Cryo-em structure of human bradykinin receptor bk2r in complex gq proteins and bradykinin

Structure:

Bradykinin receptor bk2r. Chain: a. Engineered: yes. Bradykinin. Chain: l. Engineered: yes. Other_details: this peptide is the ligand of the protein bradykinin receptor b2r. Guanine nucleotide-binding protein g(q) subunit alpha.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Human. Gene: gnaq, gaq. Gene: gnb1. Gene: gng2.

Authors:

J.Shen,D.Zhang,Y.Fu,A.Chen,H.Zhang

Key ref:

H.Zhang Cryo-Em structure of human bradykinin receptor bk2r i complex with gq proteins and bradykinin. To be published, . PubMed id: 35132089

Date:

25-Jun-21 Release date: 05-Jan-22

Protein chain

P30411  (BKRB2_HUMAN) -  B2 bradykinin receptor from Homo sapiens

Seq: 391 a.a.

Struc: 305 a.a.

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 226 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 330 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 47 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????