PDBsum entry 7ezh

Membrane protein

PDB id: 7ezh

Contents

Protein chains

217 a.a.

339 a.a.

296 a.a.

56 a.a.

233 a.a.

Ligands

ASP-TYS-MET-GLY-TRP-MET-ASP-PHE-PHE

PDB id:

7ezh

Name:

Membrane protein

Title:

Cryo-em structure of an activated cholecystokinin a receptor (cckar)- gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: cckar, cckra. Gene: gng2.

Authors:

Q.F.Liu,D.H.Yang,Y.W.Zhuang,T.I.Croll,X.Q.Cai,J.Duan,A.T.Dai,W.C.Yin, C.Y.Ye,F.L.Zhou,B.L.Wu,Q.Zhao,H.E.Xu,M.W.Wang,Y.Jiang

Key ref:

Q.Liu et al. (2021). Ligand recognition and g-Protein coupling selectivity cholecystokinin a receptor. Nat chem biol, 17, 1238.

Date:

01-Jun-21 Release date: 25-Aug-21

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P32238  (CCKAR_HUMAN) -  Cholecystokinin receptor type A from Homo sapiens

Seq: 428 a.a.

Struc: 296 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????