PDBsum entry 7ex3

Hydrolase

PDB id: 7ex3

Contents

Protein chain

179 a.a.

Ligands

IA3

Metals

_CL ×3

_MN ×2

Waters ×79

PDB id:

7ex3

Name:

Hydrolase

Title:

Crystal structure of ebinur lake virus cap snatching endonuclease in complex with inhibitor 3

Structure:

Replicase. Chain: a. Fragment: n-terminal endonuclease domain. Synonym: transcriptase,l protein. Engineered: yes

Source:

Abbey lake orthobunyavirus. Organism_taxid: 1501396. Strain: cu20-xj. Gene: rdrp. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.25Å R-factor: 0.192 R-free: 0.226

Authors:

W.Kuang,Z.Hu,P.Gong

Key ref:

W.Kuang et al. Structural and biochemical basis for development of d acid inhibitors targeting the cap snatching endonucle the ebinur lake virus (order: bunyavirales). To be published, . PubMed id: 35266805

Date:

26-May-21 Release date: 16-Feb-22

Protein chain

A0A059WLS9  (A0A059WLS9_9VIRU) -  RNA-directed RNA polymerase L from Ebinur lake virus

Seq: 2238 a.a.

Struc: 179 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site