PDBsum entry 7evm

Structural protein

PDB id: 7evm

Contents

Protein chains

235 a.a.

338 a.a.

56 a.a.

126 a.a.

282 a.a.

Ligands

HNO

CLR ×6

PDB id:

7evm

Name:

Structural protein

Title:

Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Rat. Organism_taxid: 10116.

Authors:

Z.Cong,L.Chen,H.Ma,Q.Zhou,X.Zou,C.Ye,A.Dai,Q.Liu,W.Huang,X.Sun, X.Wang,P.Xu,L.Zhao,T.Xia,W.Zhong,D.Yang,H.E.Xu,Y.Zhang,M.Wang

Date:

21-May-21 Release date: 11-Aug-21

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 235 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 282 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????