PDBsum entry 7elc

Viral protein/RNA

PDB id: 7elc

Contents

Protein chains

1409 a.a.

49 a.a.

DNA/RNA

Metals

_ZN ×4

_MN

PDB id:

7elc

Name:

Viral protein/RNA

Title:

Structure of monomeric complex of macv l bound to z and 3'-vrna

Structure:

RNA-directed RNA polymerase l. Chain: a. Synonym: protein l,large structural protein,replicase,transcriptase. Engineered: yes. Ring finger protein z. Chain: b. Synonym: protein z,zinc-binding protein. Engineered: yes. 3'-vrna promoter.

Source:

Machupo mammarenavirus. Macv. Organism_taxid: 11628. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148. Other_details: baculovirus expression system. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.

Authors:

X.Xu,R.Peng,Q.Peng,Y.Shi

Key ref:

R.Peng et al. Cryo-Em structures of lassa and machupo virus polymer complexed with cognate regulatory z proteins identify targets for antivirals.. Nat microbiol, . PubMed id: 34127846

Date:

09-Apr-21 Release date: 05-May-21

Protein chain

Q6IVU0  (Q6IVU0_MACHU) -  RNA-directed RNA polymerase L from Machupo virus

Seq: 2209 a.a.

Struc: 1409 a.a.

Protein chain

Q6UY77  (Q6UY77_MACHU) -  RING finger protein Z from Machupo virus

Seq: 94 a.a.

Struc: 49 a.a.

DNA/RNA chain

C-U-G-U-G-C-G 7 bases

Enzyme reactions

• Enzyme class 2: Chain A: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
• Enzyme class 3: Chain A: E.C.3.1.-.-

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site