PDBsum entry 7e4z

Structural protein/inhibitor

PDB id: 7e4z

Contents

Protein chains

440 a.a.

425 a.a.

123 a.a.

348 a.a.

Ligands

GTP ×3

MES ×3

GDP

BKL

ACP

Metals

_MG ×5

_CA ×4

_CL

Waters ×374

PDB id:

7e4z

Name:

Structural protein/inhibitor

Title:

Crystal structure of tubulin in complex with maytansinol

Structure:

Tubulin alpha-1b chain. Chain: a, c. Synonym: alpha-tubulin ubiquitous,tubulin k-alpha-1,tubulin alpha- ubiquitous chain. Engineered: yes. Tubulin beta-2b chain. Chain: b, d. Engineered: yes. Stathmin-4.

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tubb2b. Rattus norvegicus. Rat. Organism_taxid: 10116.

Resolution:

2.69Å R-factor: 0.194 R-free: 0.228

Authors:

Y.Wang,W.Li

Key ref:

W.Li et al. (2021). C3 ester side chain plays a pivotal role in the antit activity of maytansinoids.. Biochem biophys res commun, 566, 197. PubMed id: 34144258

Date:

16-Feb-21 Release date: 07-Jul-21

Protein chains

P81947  (TBA1B_BOVIN) -  Tubulin alpha-1B chain from Bos taurus

Seq: 451 a.a.

Struc: 440 a.a.

Protein chains

Q6B856  (TBB2B_BOVIN) -  Tubulin beta-2B chain from Bos taurus

Seq: 445 a.a.

Struc: 425 a.a.

Protein chain

P63043  (STMN4_RAT) -  Stathmin-4 from Rattus norvegicus

Seq: 189 a.a.

Struc: 123 a.a.

Protein chain

E1BQ43  (E1BQ43_CHICK) -