PDBsum entry 7cme

Cell adhesion

PDB id: 7cme

Contents

Protein chains

214 a.a.

Ligands

DMS ×2

G60 ×3

Metals

_CA ×6

Waters ×29

PDB id:

7cme

Name:

Cell adhesion

Title:

Crystal structure of human p-cadherin mec12 (x dimer) in complex with 2-(5-chloro-2-methyl-1h-indol-3-yl)ethan-1-amine (inhibitor)

Structure:

Cadherin-3. Chain: a, b. Synonym: placental cadherin,p-cadherin. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cdh3, cdhp. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.45Å R-factor: 0.211 R-free: 0.249

Authors:

A.Senoo,S.Ito,G.Ueno,S.Nagatoishi,K.Tsumoto

Key ref:

A.Senoo et al. (2021). Regulation of cadherin dimerization by chemical fragm a trigger to inhibit cell adhesion. Commun biol, 4, 1041.

Date:

27-Jul-20 Release date: 15-Sep-21

Protein chains

P22223  (CADH3_HUMAN) -  Cadherin-3 from Homo sapiens

Seq: 829 a.a.

Struc: 214 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?