PDBsum entry 7cc2

Transferase

PDB id: 7cc2

Contents

Protein chains

263 a.a.

Ligands

FVC ×2

Waters ×45

PDB id:

7cc2

Name:

Transferase

Title:

Strategic design of catalytic lysine-targeting reversible covalent bcr-abl inhibitors

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Synonym: abelson murine leukemia viral oncogene homolog 1,abelson tyrosine-protein kinase 1,proto-oncogenE C-abl,p150. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.72Å R-factor: 0.196 R-free: 0.242

Authors:

J.Anantharajan,N.Baburajendran

Key ref:

D.Quach et al. Strategic design of catalytic lysine-Targeting revers covalent bcr-Abl inhibitors.. Angew chem int ed engl, . PubMed id: 34008286

Date:

16-Jun-20 Release date: 09-Jun-21

Protein chains

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 263 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site